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Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations

Cutaneous melanoma is an aggressive malignant tumor of melanocytes which accounts for 80% of skin cancer-related deaths. A number of driver mutations have been identified in melanoma, with the mutually exclusive BRAF V600E and NRAS Q61A mutations together accounting for roughly 70% of mutations. Sim...

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Detalles Bibliográficos
Autores principales: Shackelford, Rodney, Pollen, Maressa, Vora, Moise, Jusion, Tamara T., Cotelingam, James, Nair, Binu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035678/
https://www.ncbi.nlm.nih.gov/pubmed/24926260
http://dx.doi.org/10.1159/000362788