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A fully genetically-encoded protein architecture for optical control of peptide ligand concentration

Ion channels are amongst the most important proteins in biology - regulating the activity of excitable cells and changing in diseases. Ideally it would be possible to actuate endogenous ion channels, in a temporally precise and reversible fashion, and without requiring chemical co-factors. Here we p...

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Detalles Bibliográficos
Autores principales: Schmidt, Daniel, Tillberg, Paul W., Chen, Fei, Boyden, Edward S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035689/
https://www.ncbi.nlm.nih.gov/pubmed/24407101
http://dx.doi.org/10.1038/ncomms4019