Genetic targeting of B-Raf(V600E) affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells

BACKGROUND: Colorectal cancers carrying the B-Raf V600E-mutation are associated with a poor prognosis. The purpose of this study was to identify B-Raf(V600E)-mediated traits of cancer cells in a genetic in vitro model and to assess the selective sensitization of B-Raf(V600E)-mutant cancer cells towa...

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Detalles Bibliográficos
Autores principales: Hirschi, Benjamin, Gallmeier, Eike, Ziesch, Andreas, Marschall, Maximilian, Kolligs, Frank T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035728/
https://www.ncbi.nlm.nih.gov/pubmed/24885690
http://dx.doi.org/10.1186/1476-4598-13-122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035728/
https://www.ncbi.nlm.nih.gov/pubmed/24885690
http://dx.doi.org/10.1186/1476-4598-13-122

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