Synthesis, Screening and Pharmacokinetic Evaluation of Potential Prodrugs of Bupropion. Part One: In Vitro Development

In general, prodrugs are developed to circumvent deficiencies associated with the absorption, distribution, metabolism, excretion or toxicological (ADMET) profile associated with the active drug. In our study, we select bupropion, a drug with broad pharmacology incorporating dopaminergic, noradrener...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Byrne, Paul Matthew, Williams, Robert, Walsh, John J., Gilmer, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035770/
https://www.ncbi.nlm.nih.gov/pubmed/24830986
http://dx.doi.org/10.3390/ph7050595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035770/
https://www.ncbi.nlm.nih.gov/pubmed/24830986
http://dx.doi.org/10.3390/ph7050595

Ejemplares similares