The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s disease (AD). Mutations of the BRICHOS chaperone domain are associated with amyloid disease and recent in vitro data show that BRICHOS efficiently delays Aβ42 oligomerizatio...

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Detalles Bibliográficos
Autores principales: Hermansson, Erik, Schultz, Sebastian, Crowther, Damian, Linse, Sara, Winblad, Bengt, Westermark, Gunilla, Johansson, Jan, Presto, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036473/
https://www.ncbi.nlm.nih.gov/pubmed/24682783
http://dx.doi.org/10.1242/dmm.014787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036473/
https://www.ncbi.nlm.nih.gov/pubmed/24682783
http://dx.doi.org/10.1242/dmm.014787

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