Demethylating Agents in the Treatment of Cancer

Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis. Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate and induce silenced gene re-expression in malignancies. Two demethylating agents, azacitidine and decitabine, are approved fo...

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Detalles Bibliográficos
Autores principales: Howell, Paul M., Liu, Zixing, Khong, Hung T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036667/
https://www.ncbi.nlm.nih.gov/pubmed/27713340
http://dx.doi.org/10.3390/ph3072022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036667/
https://www.ncbi.nlm.nih.gov/pubmed/27713340
http://dx.doi.org/10.3390/ph3072022

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