Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

BACKGROUND: DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation. This is accompanied by major chromatin remodelling and generates a marked asym...

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Detalles Bibliográficos
Autores principales: Santos, Fátima, Peat, Julian, Burgess, Heather, Rada, Cristina, Reik, Wolf, Dean, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037648/
https://www.ncbi.nlm.nih.gov/pubmed/24279473
http://dx.doi.org/10.1186/1756-8935-6-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037648/
https://www.ncbi.nlm.nih.gov/pubmed/24279473
http://dx.doi.org/10.1186/1756-8935-6-39

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