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Active demethylation in mouse zygotes involves cytosine deamination and base excision repair
BACKGROUND: DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation. This is accompanied by major chromatin remodelling and generates a marked asym...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037648/ https://www.ncbi.nlm.nih.gov/pubmed/24279473 http://dx.doi.org/10.1186/1756-8935-6-39 |