Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells

CRISPR/Cas9-derived RNA-guided nucleases (RGNs) are DNA targeting systems, which are rapidly being harnessed for gene regulation and gene editing purposes in model organisms and cell lines. As bona fide gene delivery vehicles, viral vectors may be particularly fit to broaden the applicability of RGN...

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Detalles Bibliográficos
Autores principales: Maggio, Ignazio, Holkers, Maarten, Liu, Jin, Janssen, Josephine M., Chen, Xiaoyu, Gonçalves, Manuel A. F. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037712/
https://www.ncbi.nlm.nih.gov/pubmed/24870050
http://dx.doi.org/10.1038/srep05105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037712/
https://www.ncbi.nlm.nih.gov/pubmed/24870050
http://dx.doi.org/10.1038/srep05105

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