Phase I study of weekly paclitaxel in combination with pazopanib and lapatinib in advanced solid malignancies

BACKGROUND: We assessed the maximum tolerated regimen (MTR) and dose-limiting toxicities of pazopanib and lapatinib in combination with weekly paclitaxel, and the effect of pazopanib and lapatinib on paclitaxel pharmacokinetics. METHODS: Patients received intravenous paclitaxel on days 1, 8, and 15...

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Detalles Bibliográficos
Autores principales: Tan, A R, Dowlati, A, Stein, M N, Jones, S F, Infante, J R, Bendell, J, Kane, M P, Levinson, K T, Suttle, A B, Burris III, H A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037836/
https://www.ncbi.nlm.nih.gov/pubmed/24800949
http://dx.doi.org/10.1038/bjc.2014.233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037836/
https://www.ncbi.nlm.nih.gov/pubmed/24800949
http://dx.doi.org/10.1038/bjc.2014.233

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