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The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

[Image: see text] Diabetes-induced hyperglycemia increases the extracellular concentration of methylglyoxal. Methylglyoxal-derived hydroimidazolones (MG-H) form advanced glycation end products (AGEs) that accumulate in the serum of diabetic patients. The binding of hydroimidozolones to the receptor...

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Detalles Bibliográficos
Autores principales: Xue, Jing, Ray, Rashmi, Singer, David, Böhme, David, Burz, David S., Rai, Vivek, Hoffmann, Ralf, Shekhtman, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038343/
https://www.ncbi.nlm.nih.gov/pubmed/24824951
http://dx.doi.org/10.1021/bi500046t