Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas

Genetic and epigenetic (DNA methylation, histone modifications, microRNA expression) crosstalk promotes inactivation of tumor suppressor genes or activation of oncogenes by gene loss/hypermethylation or duplications/hypomethylation, respectively. The 8p11-p12 chromosomal region is a hotspot for geno...

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Detalles Bibliográficos
Autores principales: Parris, T Z, Kovács, A, Hajizadeh, S, Nemes, S, Semaan, M, Levin, M, Karlsson, P, Helou, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038389/
https://www.ncbi.nlm.nih.gov/pubmed/24662924
http://dx.doi.org/10.1038/oncsis.2014.8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038389/
https://www.ncbi.nlm.nih.gov/pubmed/24662924
http://dx.doi.org/10.1038/oncsis.2014.8

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