Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders

BACKGROUND: Identification of ligand-protein binding interactions is a critical step in drug discovery. Experimental screening of large chemical libraries, in spite of their specific role and importance in drug discovery, suffer from the disadvantages of being random, time-consuming and expensive. T...

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Detalles Bibliográficos
Autores principales: Srinivasan, Bharath, Zhou, Hongyi, Kubanek, Julia, Skolnick, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038399/
https://www.ncbi.nlm.nih.gov/pubmed/24936211
http://dx.doi.org/10.1186/1758-2946-6-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038399/
https://www.ncbi.nlm.nih.gov/pubmed/24936211
http://dx.doi.org/10.1186/1758-2946-6-16

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