Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

We show here that human embryonic stem (ES) and induced pluripotent stem cell–derived neuroprogenitors (NPs) develop primary cilia. Ciliogenesis depends on the sphingolipid ceramide and its interaction with atypical PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell...

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Detalles Bibliográficos
Autores principales: He, Qian, Wang, Guanghu, Wakade, Sushama, Dasgupta, Somsankar, Dinkins, Michael, Kong, Ji Na, Spassieva, Stefka D., Bieberich, Erhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038499/
https://www.ncbi.nlm.nih.gov/pubmed/24694597
http://dx.doi.org/10.1091/mbc.E13-12-0730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038499/
https://www.ncbi.nlm.nih.gov/pubmed/24694597
http://dx.doi.org/10.1091/mbc.E13-12-0730

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