Deficient Production of Reactive Oxygen Species Leads to Severe Chronic DSS-Induced Colitis in Ncf1/p47(phox)-Mutant Mice

BACKGROUND: Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colit...

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Detalles Bibliográficos
Autores principales: Rodrigues-Sousa, Tiago, Ladeirinha, Ana Filipa, Santiago, Ana Raquel, Carvalheiro, Helena, Raposo, Bruno, Alarcão, Ana, Cabrita, António, Holmdahl, Rikard, Carvalho, Lina, Souto-Carneiro, M. Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038546/
https://www.ncbi.nlm.nih.gov/pubmed/24873968
http://dx.doi.org/10.1371/journal.pone.0097532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038546/
https://www.ncbi.nlm.nih.gov/pubmed/24873968
http://dx.doi.org/10.1371/journal.pone.0097532

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