Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated K22, that specifically targets membrane-bound corona...

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Detalles Bibliográficos
Autores principales: Lundin, Anna, Dijkman, Ronald, Bergström, Tomas, Kann, Nina, Adamiak, Beata, Hannoun, Charles, Kindler, Eveline, Jónsdóttir, Hulda R., Muth, Doreen, Kint, Joeri, Forlenza, Maria, Müller, Marcel A., Drosten, Christian, Thiel, Volker, Trybala, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038610/
https://www.ncbi.nlm.nih.gov/pubmed/24874215
http://dx.doi.org/10.1371/journal.ppat.1004166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038610/
https://www.ncbi.nlm.nih.gov/pubmed/24874215
http://dx.doi.org/10.1371/journal.ppat.1004166

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