New Insights into Rotavirus Entry Machinery: Stabilization of Rotavirus Spike Conformation Is Independent of Trypsin Cleavage

The infectivity of rotavirus, the main causative agent of childhood diarrhea, is dependent on activation of the extracellular viral particles by trypsin-like proteases in the host intestinal lumen. This step entails proteolytic cleavage of the VP4 spike protein into its mature products, VP8* and VP5...

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Detalles Bibliográficos
Autores principales: Rodríguez, Javier M., Chichón, Francisco J., Martín-Forero, Esther, González-Camacho, Fernando, Carrascosa, José L., Castón, José R., Luque, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038622/
https://www.ncbi.nlm.nih.gov/pubmed/24873828
http://dx.doi.org/10.1371/journal.ppat.1004157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038622/
https://www.ncbi.nlm.nih.gov/pubmed/24873828
http://dx.doi.org/10.1371/journal.ppat.1004157

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