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The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration
BACKGROUND: Opioids are the cornerstone of treatment for moderate to severe pain, but chronic use leads to maladaptations that include: tolerance, dependence and opioid-induced hyperalgesia (OIH). These responses limit the utility of opioids, as well as our ability to control chronic pain. Despite d...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038717/ https://www.ncbi.nlm.nih.gov/pubmed/24884839 http://dx.doi.org/10.1186/1471-2164-15-345 |