SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

Histone modifications establish the chromatin states that coordinate the DNA damage response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 lysine 36 (H3K36me3), is required for ATM activation upon DNA double-strand breaks (DSBs). Moreover, we find that SETD2 is necessa...

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Detalles Bibliográficos
Autores principales: Carvalho, Sílvia, Vítor, Alexandra C, Sridhara, Sreerama C, Martins, Filipa B, Raposo, Ana C, Desterro, Joana MP, Ferreira, João, de Almeida, Sérgio F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038841/
https://www.ncbi.nlm.nih.gov/pubmed/24843002
http://dx.doi.org/10.7554/eLife.02482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038841/
https://www.ncbi.nlm.nih.gov/pubmed/24843002
http://dx.doi.org/10.7554/eLife.02482

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