Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction

During mitotic entry, centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase centrosomes are physically tethered by a proteinaceous linker composed of C-Nap1 (also known as CEP250)...

Descripción completa

Detalles Bibliográficos
Autores principales: Hardy, Tara, Lee, Miseon, Hames, Rebecca S., Prosser, Suzanna L., Cheary, Donna-Marie, Samant, Mugdha D., Schultz, Francisca, Baxter, Joanne E., Rhee, Kunsoo, Fry, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038944/
https://www.ncbi.nlm.nih.gov/pubmed/24695856
http://dx.doi.org/10.1242/jcs.142331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038944/
https://www.ncbi.nlm.nih.gov/pubmed/24695856
http://dx.doi.org/10.1242/jcs.142331

Ejemplares similares