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Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction
During mitotic entry, centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase centrosomes are physically tethered by a proteinaceous linker composed of C-Nap1 (also known as CEP250)...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038944/ https://www.ncbi.nlm.nih.gov/pubmed/24695856 http://dx.doi.org/10.1242/jcs.142331 |