Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis

Gentamicin C complex is a mixture of aminoglycoside antibiotics used to treat severe Gram-negative bacterial infections. We report here key features of the late-stage biosynthesis of gentamicins. We show that the intermediate gentamicin X2, a known substrate for C-methylation at C-6′ to form G418 ca...

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Detalles Bibliográficos
Autores principales: Guo, Junhong, Huang, Fanglu, Huang, Chuan, Duan, Xiaobo, Jian, Xinyun, Leeper, Finian, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039129/
https://www.ncbi.nlm.nih.gov/pubmed/24746560
http://dx.doi.org/10.1016/j.chembiol.2014.03.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039129/
https://www.ncbi.nlm.nih.gov/pubmed/24746560
http://dx.doi.org/10.1016/j.chembiol.2014.03.005

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