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Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis
Gentamicin C complex is a mixture of aminoglycoside antibiotics used to treat severe Gram-negative bacterial infections. We report here key features of the late-stage biosynthesis of gentamicins. We show that the intermediate gentamicin X2, a known substrate for C-methylation at C-6′ to form G418 ca...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039129/ https://www.ncbi.nlm.nih.gov/pubmed/24746560 http://dx.doi.org/10.1016/j.chembiol.2014.03.005 |