Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

We hypothesized that elucidating the interactome of epidermal growth factor receptor (EGFR) forms that are mutated in lung cancer, via global analysis of protein–protein interactions, phosphorylation, and systematically perturbing the ensuing network nodes, should offer a new, more systems-level per...

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Detalles Bibliográficos
Autores principales: Li, Jiannong, Bennett, Keiryn, Stukalov, Alexey, Fang, Bin, Zhang, Guolin, Yoshida, Takeshi, Okamoto, Isamu, Kim, Jae-Young, Song, Lanxi, Bai, Yun, Qian, Xiaoning, Rawal, Bhupendra, Schell, Michael, Grebien, Florian, Winter, Georg, Rix, Uwe, Eschrich, Steven, Colinge, Jacques, Koomen, John, Superti-Furga, Giulio, Haura, Eric B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039310/
https://www.ncbi.nlm.nih.gov/pubmed/24189400
http://dx.doi.org/10.1038/msb.2013.61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039310/
https://www.ncbi.nlm.nih.gov/pubmed/24189400
http://dx.doi.org/10.1038/msb.2013.61

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