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Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain

BACKGROUND: Substance P is an important neuropeptide released from nociceptors to mediate pain signals. We recently revealed antinociceptive signaling by substance P in acid-sensing ion channel 3 (ASIC3)-expressing muscle nociceptors in a mouse model of acid-induced chronic widespread pain. However,...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Nan, Chen, Chih-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039541/
https://www.ncbi.nlm.nih.gov/pubmed/24886508
http://dx.doi.org/10.1186/1744-8069-10-30