Conformational changes required for H(+)/Cl– exchange mediated by a CLC transporter

CLC-type exchangers mediate transmembrane Cl(–) transport. Mutations altering their gating properties cause numerous genetic disorders. However, their transport mechanism remains poorly understood. In conventional models two gates alternatively expose substrate(s) to the intra- or extra-cellular sol...

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Detalles Bibliográficos
Autores principales: Basilio, Daniel, Noack, Kristin, Picollo, Alessandra, Accardi, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040230/
https://www.ncbi.nlm.nih.gov/pubmed/24747941
http://dx.doi.org/10.1038/nsmb.2814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040230/
https://www.ncbi.nlm.nih.gov/pubmed/24747941
http://dx.doi.org/10.1038/nsmb.2814

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