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Conformational changes required for H(+)/Cl– exchange mediated by a CLC transporter
CLC-type exchangers mediate transmembrane Cl(–) transport. Mutations altering their gating properties cause numerous genetic disorders. However, their transport mechanism remains poorly understood. In conventional models two gates alternatively expose substrate(s) to the intra- or extra-cellular sol...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040230/ https://www.ncbi.nlm.nih.gov/pubmed/24747941 http://dx.doi.org/10.1038/nsmb.2814 |