PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN

GATA1 mutations are tightly associated with transient myeloproliferative disorder (TMD) and acute megakaryoblstic leukemia (AMKL) in children with Down syndrome. Numerous genes are altered in GATA-1-deficient megakaryocytes, which may contribute to the hyperproliferation and abnormal terminal differ...

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Detalles Bibliográficos
Autores principales: Liu, L, Wen, Q, Gong, R, Gilles, L, Stankiewicz, M J, Li, W, Guo, M, Li, L, Sun, X, Crispino, J D, Huang, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040682/
https://www.ncbi.nlm.nih.gov/pubmed/24407241
http://dx.doi.org/10.1038/cddis.2013.512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040682/
https://www.ncbi.nlm.nih.gov/pubmed/24407241
http://dx.doi.org/10.1038/cddis.2013.512

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