The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function

The B-cell CLL/lymphoma-2 (Bcl-2) family of proteins are important regulators of the intrinsic pathway of apoptosis, and their interactions, driven by Bcl-2 homology (BH) domains, are of great interest in cancer research. Particularly, the BH3 domain is of clinical relevance, as it promotes apoptosi...

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Detalles Bibliográficos
Autores principales: Stadler, L K J, Tomlinson, D C, Lee, T, Knowles, M A, Ko Ferrigno, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040713/
https://www.ncbi.nlm.nih.gov/pubmed/24481451
http://dx.doi.org/10.1038/cddis.2013.564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040713/
https://www.ncbi.nlm.nih.gov/pubmed/24481451
http://dx.doi.org/10.1038/cddis.2013.564

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