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Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy
Cell signaling is often mediated by the binding of multiple ligands to a multi-subunit receptor. The probabilistic nature and slow rate of binding of diffusible ligands at low concentrations can impede attempts to determine how ligand occupancy controls signaling in such protein complexes. We descri...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041372/ https://www.ncbi.nlm.nih.gov/pubmed/24561661 http://dx.doi.org/10.1038/nchembio.1458 |