Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans

Adenosine deaminases that act on RNA (ADAR) are a class of enzymes that catalyze the conversion of adenosine to inosine in RNA. Since inosine is read as guanosine ADAR activity formally introduces A-to-G point mutations. Re-addressing ADAR activity toward new targets in an RNA-dependent manner is a...

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Detalles Bibliográficos
Autores principales: Schneider, Marius F., Wettengel, Jacqueline, Hoffmann, Patrick C., Stafforst, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041445/
https://www.ncbi.nlm.nih.gov/pubmed/24744243
http://dx.doi.org/10.1093/nar/gku272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041445/
https://www.ncbi.nlm.nih.gov/pubmed/24744243
http://dx.doi.org/10.1093/nar/gku272

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