Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

In response to genotoxic stress the TP53 tumour suppressor activates target gene expression to induce cell cycle arrest or apoptosis depending on the extent of DNA damage. These canonical activities can be repressed by TP63 in normal stratifying epithelia to maintain proliferative capacity or drive...

Descripción completa

Detalles Bibliográficos
Autores principales: McDade, Simon S., Patel, Daksha, Moran, Michael, Campbell, James, Fenwick, Kerry, Kozarewa, Iwanka, Orr, Nicholas J., Lord, Christopher J., Ashworth, Alan A., McCance, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041465/
https://www.ncbi.nlm.nih.gov/pubmed/24823795
http://dx.doi.org/10.1093/nar/gku299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041465/
https://www.ncbi.nlm.nih.gov/pubmed/24823795
http://dx.doi.org/10.1093/nar/gku299

Ejemplares similares