Cargando…

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

In response to genotoxic stress the TP53 tumour suppressor activates target gene expression to induce cell cycle arrest or apoptosis depending on the extent of DNA damage. These canonical activities can be repressed by TP63 in normal stratifying epithelia to maintain proliferative capacity or drive...

Descripción completa

Detalles Bibliográficos
Autores principales:	McDade, Simon S., Patel, Daksha, Moran, Michael, Campbell, James, Fenwick, Kerry, Kozarewa, Iwanka, Orr, Nicholas J., Lord, Christopher J., Ashworth, Alan A., McCance, Dennis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041465/ https://www.ncbi.nlm.nih.gov/pubmed/24823795 http://dx.doi.org/10.1093/nar/gku299

Ejemplares similares

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation
por: McDade, Simon S., et al.
Publicado: (2012)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma
por: Huang, Yongsheng, et al.
Publicado: (2021)

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis
por: Gorski, Julia J., et al.
Publicado: (2011)

Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism
por: Kim, Sang Hwa, et al.
Publicado: (2016)

The interplay between DNA methylation and sequence divergence in recent human evolution
por: Hernando-Herraez, Irene, et al.
Publicado: (2015)

Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes
por: Sethi, Isha, et al.
Publicado: (2017)

Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress
por: Choi, Soo-Youn, et al.
Publicado: (2013)

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle
por: Heyne, Kristina, et al.
Publicado: (2010)

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis
por: Lemeille, Sylvain, et al.
Publicado: (2020)

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
por: Nagarajan, Sankari, et al.
Publicado: (2017)

Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties
por: Lim, Ci Ji, et al.
Publicado: (2014)

The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress
por: Lemaitre, Florence, et al.
Publicado: (2022)

A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms
por: Antonini, Dario, et al.
Publicado: (2015)

XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys(63)-linked polyubiquitination
por: Park, Catherine V., et al.
Publicado: (2017)

Nucleosome positioning and kinetics near transcription-start-site barriers are controlled by interplay between active remodeling and DNA sequence
por: Parmar, Jyotsana J., et al.
Publicado: (2014)

Interplay between small RNA pathways shapes chromatin landscapes in C. elegans
por: Gushchanskaia, Ekaterina S, et al.
Publicado: (2019)

Repression of a large number of genes requires interplay between homologous recombination and HIRA
por: Misova, Ivana, et al.
Publicado: (2021)

ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress
por: Pal, Sujay, et al.
Publicado: (2022)

The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin
por: Ryan, Daniel P, et al.
Publicado: (2018)

Functional interplay between Mediator and RNA polymerase II in Rad2/XPG loading to the chromatin
por: Georges, Adrien, et al.
Publicado: (2019)

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation
por: Deng, Tao, et al.
Publicado: (2017)

Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress
por: Jeon, Bu-Nam, et al.
Publicado: (2014)

Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation
por: Tediose, Teeo, et al.
Publicado: (2010)

A dynamic interplay of nucleosome and Msn2 binding regulates kinetics of gene activation and repression following stress
por: Elfving, Nils, et al.
Publicado: (2014)

Functional interplay between chromatin remodeling complexes RSC, SWI/SNF and ISWI in regulation of yeast heat shock genes
por: Erkina, T. Y., et al.
Publicado: (2010)

Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors
por: Chen, Xi, et al.
Publicado: (2016)

The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II
por: Carnesecchi, Julie, et al.
Publicado: (2021)

The interplay between the Argonaute proteins Piwi and Aub within Drosophila germarium is critical for oogenesis, piRNA biogenesis and TE silencing
por: Théron, Emmanuelle, et al.
Publicado: (2018)

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation
por: Debaize, Lydie, et al.
Publicado: (2018)

Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins
por: Kemme, Catherine A., et al.
Publicado: (2017)

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness
por: Lee, Sung-Hun, et al.
Publicado: (2016)

DNA sequence elements required for partitioning competence of the Saccharomyces cerevisiae 2-micron plasmid STB locus
por: McQuaid, Mary E, et al.
Publicado: (2019)

The eIF3 complex of Leishmania—subunit composition and mode of recruitment to different cap-binding complexes
por: Meleppattu, Shimi, et al.
Publicado: (2015)

Psoralen mapping reveals a bacterial genome supercoiling landscape dominated by transcription
por: Visser, Bryan J, et al.
Publicado: (2022)

A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle
por: Zhang, Xiping, et al.
Publicado: (2012)

The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II
por: Connell, Zaily, et al.
Publicado: (2021)

2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
por: MacPherson, Laura, et al.
Publicado: (2013)

Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility
por: McCauley, Micah J., et al.
Publicado: (2013)

Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression
por: Kasper, Lawryn H., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0shi3ucj9gqr38d2loej05bcbf