TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

Designer nucleases have been successfully employed to modify the genomes of various model organisms and human cell types. While the specificity of zinc-finger nucleases (ZFNs) and RNA-guided endonucleases has been assessed to some extent, little data are available for transcription activator-like ef...

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Detalles Bibliográficos
Autores principales: Mussolino, Claudio, Alzubi, Jamal, Fine, Eli J., Morbitzer, Robert, Cradick, Thomas J., Lahaye, Thomas, Bao, Gang, Cathomen, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041469/
https://www.ncbi.nlm.nih.gov/pubmed/24792154
http://dx.doi.org/10.1093/nar/gku305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041469/
https://www.ncbi.nlm.nih.gov/pubmed/24792154
http://dx.doi.org/10.1093/nar/gku305

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