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Direct Sequencing from the Minimal Number of DNA Molecules Needed to Fill a 454 Picotiterplate
The large amount of DNA needed to prepare a library in next generation sequencing protocols hinders direct sequencing of small DNA samples. This limitation is usually overcome by the enrichment of such samples with whole genome amplification (WGA), mostly by multiple displacement amplification (MDA)...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041646/ https://www.ncbi.nlm.nih.gov/pubmed/24887077 http://dx.doi.org/10.1371/journal.pone.0097379 |