Differential Effects of Omeprazole and Lansoprazole Enantiomers on Aryl Hydrocarbon Receptor in Human Hepatocytes and Cell Lines

Proton pump inhibitors omeprazole and lansoprazole contain chiral sulfur atom and they are administered as a racemate, i.e. equimolar mixture of S- and R-enantiomers. The enantiopure drugs esomeprazole and dexlansoprazole have been developed and introduced to clinical practice due to their improved...

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Detalles Bibliográficos
Autores principales: Novotna, Aneta, Srovnalova, Alzbeta, Svecarova, Michaela, Korhonova, Martina, Bartonkova, Iveta, Dvorak, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041848/
https://www.ncbi.nlm.nih.gov/pubmed/24887303
http://dx.doi.org/10.1371/journal.pone.0098711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041848/
https://www.ncbi.nlm.nih.gov/pubmed/24887303
http://dx.doi.org/10.1371/journal.pone.0098711

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