Gain-of-function mutation in Gnao1: A murine model of epileptiform encephalopathy (EIEE17)?

G protein-coupled receptors strongly modulate neuronal excitability but there has been little evidence for G protein mechanisms in genetic epilepsies. Recently, four patients with epileptic encephalopathy (EIEE17) were found to have mutations in GNAO1, the most abundant G protein in brain, but the m...

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Detalles Bibliográficos
Autores principales: Kehrl, Jason M., Sahaya, Kinshuk, Dalton, Hans M., Charbeneau, Raelene A., Kohut, Kevin T., Gilbert, Kristen, Pelz, Madeline C., Parent, Jack, Neubig, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042023/
https://www.ncbi.nlm.nih.gov/pubmed/24700286
http://dx.doi.org/10.1007/s00335-014-9509-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042023/
https://www.ncbi.nlm.nih.gov/pubmed/24700286
http://dx.doi.org/10.1007/s00335-014-9509-z

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