Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

Mutations in the Tsc1 or Tsc2 genes cause tuberous sclerosis complex (TSC). Tsc1 and Tsc2 proteins form a complex that inhibits mammalian target of rapamycin complex 1 (mTORC1) signalling through Rheb-GTPase. We found that Tsc2(+/−) neurons showed impaired spine synapse formation, which was resistan...

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Detalles Bibliográficos
Autores principales: Yasuda, Shin, Sugiura, Hiroko, Katsurabayashi, Shutaro, Shimada, Tadayuki, Tanaka, Hidekazu, Takasaki, Kotaro, Iwasaki, Katsunori, Kobayashi, Toshiyuki, Hino, Okio, Yamagata, Kanato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042127/
https://www.ncbi.nlm.nih.gov/pubmed/24889507
http://dx.doi.org/10.1038/srep05155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042127/
https://www.ncbi.nlm.nih.gov/pubmed/24889507
http://dx.doi.org/10.1038/srep05155

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