Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction accuracy of potential herb–drug interactions using the semipurified milk thistle preparation, silibinin, as an exemplar herbal product. Interactions between sili...

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Detalles Bibliográficos
Autores principales: Brantley, S J, Gufford, B T, Dua, R, Fediuk, D J, Graf, T N, Scarlett, Y V, Frederick, K S, Fisher, M B, Oberlies, N H, Paine, M F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042458/
https://www.ncbi.nlm.nih.gov/pubmed/24670388
http://dx.doi.org/10.1038/psp.2013.69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042458/
https://www.ncbi.nlm.nih.gov/pubmed/24670388
http://dx.doi.org/10.1038/psp.2013.69

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