A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice

Many Alzheimer’s disease (AD) patients suffer from cerebrovascular abnormalities such as altered cerebral blood flow and cerebral microinfarcts. Recently, fibrinogen has been identified as a strong cerebrovascular risk factor in AD, as it specifically binds to β-amyloid (Aβ), thereby altering fibrin...

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Detalles Bibliográficos
Autores principales: Ahn, Hyung Jin, Glickman, J. Fraser, Poon, Ka Lai, Zamolodchikov, Daria, Jno-Charles, Odella C., Norris, Erin H., Strickland, Sidney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042638/
https://www.ncbi.nlm.nih.gov/pubmed/24821909
http://dx.doi.org/10.1084/jem.20131751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042638/
https://www.ncbi.nlm.nih.gov/pubmed/24821909
http://dx.doi.org/10.1084/jem.20131751

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