Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular endothelial growth factor A (VEGF) to enhance arteriogenesis. We report that NRP1 contributes to angiogenesis through a nove...

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Detalles Bibliográficos
Autores principales: Raimondi, Claudio, Fantin, Alessandro, Lampropoulou, Anastasia, Denti, Laura, Chikh, Anissa, Ruhrberg, Christiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042645/
https://www.ncbi.nlm.nih.gov/pubmed/24863063
http://dx.doi.org/10.1084/jem.20132330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042645/
https://www.ncbi.nlm.nih.gov/pubmed/24863063
http://dx.doi.org/10.1084/jem.20132330

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