PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice

The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial function and insulin secretion in β-cells, and the re...

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Detalles Bibliográficos
Autores principales: Deas, Emma, Piipari, Kaisa, Machhada, Asif, Li, Abi, Gutierrez-del-Arroyo, Ana, Withers, Dominic J., Wood, Nicholas W., Abramov, Andrey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042854/
https://www.ncbi.nlm.nih.gov/pubmed/24806840
http://dx.doi.org/10.1098/rsob.140051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042854/
https://www.ncbi.nlm.nih.gov/pubmed/24806840
http://dx.doi.org/10.1098/rsob.140051

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