USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation...

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Detalles Bibliográficos
Autores principales: Herhaus, Lina, Al-Salihi, Mazin A., Dingwell, Kevin S., Cummins, Timothy D., Wasmus, Lize, Vogt, Janis, Ewan, Richard, Bruce, David, Macartney, Thomas, Weidlich, Simone, Smith, James C., Sapkota, Gopal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042855/
https://www.ncbi.nlm.nih.gov/pubmed/24850914
http://dx.doi.org/10.1098/rsob.140065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042855/
https://www.ncbi.nlm.nih.gov/pubmed/24850914
http://dx.doi.org/10.1098/rsob.140065

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