Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development

The transcription factor Tbx5 is expressed in the developing heart, eyes and anterior appendages. Mutations in human TBX5 cause Holt–Oram syndrome, a condition characterized by heart and upper limb malformations. Tbx5-knockout mouse embryos have severely impaired forelimb and heart morphogenesis fro...

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Detalles Bibliográficos
Autores principales: Pi-Roig, Aina, Martin-Blanco, Enrique, Minguillon, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043114/
https://www.ncbi.nlm.nih.gov/pubmed/24759614
http://dx.doi.org/10.1098/rsob.140014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043114/
https://www.ncbi.nlm.nih.gov/pubmed/24759614
http://dx.doi.org/10.1098/rsob.140014

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