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A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues
Cancers are rarely caused by single mutations, but often develop as a result of the combined effects of multiple mutations. For most cells, the number of possible cell divisions is limited because of various biological constraints, such as progressive telomere shortening, cell senescence cascades or...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043170/ https://www.ncbi.nlm.nih.gov/pubmed/23740488 http://dx.doi.org/10.1098/rsif.2013.0349 |