A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing agents trigger necrosis and proteolysis of in...

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Detalles Bibliográficos
Autores principales: Brojatsch, Jürgen, Lima, Heriberto, Kar, Alak K., Jacobson, Lee S., Muehlbauer, Stefan M., Chandran, Kartik, Diaz-Griffero, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043491/
https://www.ncbi.nlm.nih.gov/pubmed/24893007
http://dx.doi.org/10.1371/journal.pone.0095032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043491/
https://www.ncbi.nlm.nih.gov/pubmed/24893007
http://dx.doi.org/10.1371/journal.pone.0095032

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