BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-κB pathway proteins

The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of...

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Detalles Bibliográficos
Autores principales: LIN, SHENGYUN, LI, JING, ZHOU, WENJING, QIAN, WENBIN, WANG, BO, CHEN, ZHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043628/
https://www.ncbi.nlm.nih.gov/pubmed/24926340
http://dx.doi.org/10.3892/etm.2014.1651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043628/
https://www.ncbi.nlm.nih.gov/pubmed/24926340
http://dx.doi.org/10.3892/etm.2014.1651

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