Shaking Alone Induces De Novo Conversion of Recombinant Prion Proteins to β-Sheet Rich Oligomers and Fibrils

The formation of β-sheet rich prion oligomers and fibrils from native prion protein (PrP) is thought to be a key step in the development of prion diseases. Many methods are available to convert recombinant prion protein into β-sheet rich fibrils using various chemical denaturants (urea, SDS, GdnHCl)...

Descripción completa

Detalles Bibliográficos
Autores principales: Ladner-Keay, Carol L., Griffith, Bethany J., Wishart, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043794/
https://www.ncbi.nlm.nih.gov/pubmed/24892647
http://dx.doi.org/10.1371/journal.pone.0098753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043794/
https://www.ncbi.nlm.nih.gov/pubmed/24892647
http://dx.doi.org/10.1371/journal.pone.0098753

Ejemplares similares