CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-α Possibly by Suppressing Oxidative Stress and PGC-1α Acetylation, and Activating the MAPK and GSK3β Pathway

BACKGROUND: Cytochrome P4502E1 (CYP2E1) has been suggested to play critical roles in the pathogenesis of alcoholic fatty liver (AFL), but the underlying mechanisms remains unclear. The current study was designed to evaluate whether CYP2E1 suppression by chlormethiazole (CMZ) could suppress AFL in mi...

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Detalles Bibliográficos
Autores principales: Zeng, Tao, Zhang, Cui-Li, Song, Fu-Yong, Zhao, Xiu-Lan, Xie, Ke-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043914/
https://www.ncbi.nlm.nih.gov/pubmed/24892905
http://dx.doi.org/10.1371/journal.pone.0098658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043914/
https://www.ncbi.nlm.nih.gov/pubmed/24892905
http://dx.doi.org/10.1371/journal.pone.0098658

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