Cargando…
CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-α Possibly by Suppressing Oxidative Stress and PGC-1α Acetylation, and Activating the MAPK and GSK3β Pathway
BACKGROUND: Cytochrome P4502E1 (CYP2E1) has been suggested to play critical roles in the pathogenesis of alcoholic fatty liver (AFL), but the underlying mechanisms remains unclear. The current study was designed to evaluate whether CYP2E1 suppression by chlormethiazole (CMZ) could suppress AFL in mi...
Autores principales: | Zeng, Tao, Zhang, Cui-Li, Song, Fu-Yong, Zhao, Xiu-Lan, Xie, Ke-Qin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043914/ https://www.ncbi.nlm.nih.gov/pubmed/24892905 http://dx.doi.org/10.1371/journal.pone.0098658 |
Ejemplares similares
-
CMZ: a source code management system
por: Brun, M, et al.
Publicado: (1989) -
PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
por: Corona, Juan Carlos, et al.
Publicado: (2014) -
PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
por: Shizu, Ryota, et al.
Publicado: (2021) -
ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
por: Khan, Salmaan Ahmed, et al.
Publicado: (2015) -
PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production
por: Wang, Chaoqun, et al.
Publicado: (2021)